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. 2012 Dec 24:414:125-129.
doi: 10.1016/j.cca.2012.08.021. Epub 2012 Sep 6.

Oxidized high-density lipoprotein is associated with increased plasma glucose in non-diabetic dyslipidemic subjects

Kazuhiko Kotani  1 , Naoki Sakane  2 , Masashi Ueda  3 , Shinichi Mashiba  3 , Yasuyuki Hayase  3 , Kokoro Tsuzaki  2 , Toshiyuki Yamada  4 , Alan T Remaley  5
Affiliations

Oxidized high-density lipoprotein is associated with increased plasma glucose in non-diabetic dyslipidemic subjects

Kazuhiko Kotani et al. Clin Chim Acta. .

Abstract

Background: Oxidized high-density lipoprotein (oxHDL) has reduced capacity for cholesterol efflux and some of other anti-atherogenic properties of HDL, but the role of oxHDL in the pathogenesis of cardiometabolic disease has not been fully demonstrated. This study investigated the association of oxHDL with plasma glucose (PG) and the other atherosclerotic risk variables in non-diabetic dyslipidemic subjects.

Methods: Conventional atherosclerotic markers and LDL particle size (LDL-PS), as determined by gel electrophoresis, were measured in 155 non-diabetic subjects (mean age of 57 years) with dyslipidemia. Serum oxHDL levels were quantified using an antibody against oxidized human apoA-I in a sandwich ELISA format.

Results: Multiple regression analysis adjusted for possible confounders revealed that HDL-cholesterol was independently, significantly and positively correlated with LDL-PS and oxHDL. By multiple regression analysis, oxHDL was independently, significantly and positively correlated with fasting PG (β=0.19, P=0.01). Subjects in the highest PG tertile group had approximately 30% higher oxHDL levels than the lowest PG tertile group.

Conclusions: These results suggest that high PG levels may contribute to the HDL oxidation, irrespective of HDL-cholesterol levels, even in non-diabetic subjects with dyslipidemia, and that the measurement of oxHDL may be a useful marker of dysfunctional HDL.

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Conflict of interest statement

Conflict of interest statement: All authors declare that they have no conflict of interest with regard to this work.

Figures

Figure 1
Figure 1
Oxidized high-density lipoprotein (HDL) levels according to the tertiles of fasting plasma glucose levels. The lowest/middle threshold level of glucose: 5.11 mmol/l, the middle/highest threshold level of plasma glucose: 5.67 mmol/l. The oxHDL levels were shown as geometric means. The comparison was analyzed by one-way ANOVA with multiple comparison tests.
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