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Editorial
. 2012 Oct 15;11(20):3705-6.
doi: 10.4161/cc.22043. Epub 2012 Sep 14.

Restoring PML tumor suppression to combat cancer

Kamil Wolyniec, Ai-Leen Chan, Sue Haupt, Ygal Haupt
Editorial

Restoring PML tumor suppression to combat cancer

Kamil Wolyniec et al. Cell Cycle. .
No abstract available

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Figures

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Figure 1. Restoration of tumor suppression by targeting negative regulators of PML using small-molecule inhibitors. Diagramatic presentation of the major inhibitors (yellow ovals) of PML by post-translational modifications, including phosphorylation, SUMOylation, isomerization, acetylation and ubiquitination. Specific inhibitors targeting several of these proteins (red ovals), two of which (XMD8–92 and emodin) have been shown to restore PML-induced tumor suppression. Combinations of small molecule inhibitors with genotoxic DNA damaging drugs (green oval) such as etoposide may prove to have a synergistic anticancer effect.
See this image and copyright information in PMC

Comment on

  • Wolyniec K, Shortt J, de Stanchina E, Levav-Cohen Y, Alsheich-Bartok O, Louria-Hayon I, Corneille V, Kumar B, Woods SJ, Opat S, Johnstone RW, Scott CL, Segal D, Pandolfi PP, Fox S, Strasser A, Jiang YH, Lowe SW, Haupt S, Haupt Y. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood. 2012;120:822–32. doi: 10.1182/blood-2011-10-387647.

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