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Review
. 2013 Apr;28(4):563-8.
doi: 10.1007/s00467-012-2309-3. Epub 2012 Sep 16.

FGF23 production by osteocytes

Lynda F Bonewald  1 , Michael J Wacker
Affiliations
Review

FGF23 production by osteocytes

Lynda F Bonewald et al. Pediatr Nephrol. 2013 Apr.

Abstract

Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.

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Figures

Figure 1
Figure 1
Examples of osteocytes and their dendrites as revealed by Bodian’s staining.
Figure 2
Figure 2
Acid-etched resin embedded cortical bone revealing the osteocyte lacunae and their canalicular system. Note the extensive number of canaliculi reaching the bone surfaces.
Figure 3
Figure 3
One osteocyte resin filled lacuna and its resin filled canalicular processes as revealed by acid-etched resin embedded bone.
See this image and copyright information in PMC

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