Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

Abstract

In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs. The HSC niche provides important cell-cell interactions and signalling molecules that regulate HSC self-renewal and differentiation processes. These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM). This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological HSC maintenance and plasma cell growth throughout MM disease progression.

Figure 1

Schematic of BMSC interactions and signalling with HSC and plasma cells. Representative signalling/adhesion molecules and their role in bone marrow stromal cell interactions with (a) HSC, (b) normal plasma cells or (c) myeloma plasma cells.