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. 2012 Sep;4(9):578-9.
doi: 10.18632/aging.100485.

Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity

Antoni Barrientos  1
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Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity

Antoni Barrientos. Aging (Albany NY). 2012 Sep.

Abstract

Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.

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Figure 1
Complementary roles of mitochondrial energy production though respiration and oxidative phosphorylation (OXPHOS) and mitochondrial ROS signaling in promoting cell survival and regulating aging and longevity.
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