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. 2013 Jan;63(1):79-85.
doi: 10.1007/s12576-012-0233-8. Epub 2012 Sep 16.

The association of ACE, ACTN3 and PPARA gene variants with strength phenotypes in middle school-age children

Ildus I Ahmetov  1   2 , Dmitry N Gavrilov  3 , Irina V Astratenkova  3 , Anastasiya M Druzhevskaya  3 , Alexandr V Malinin  3 , Elena E Romanova  3 , Victor A Rogozkin  3
Affiliations

The association of ACE, ACTN3 and PPARA gene variants with strength phenotypes in middle school-age children

Ildus I Ahmetov et al. J Physiol Sci. 2013 Jan.

Abstract

The aim of the study was to determine the association between ACE I/D, ACTN3 R577X and PPARA intron 7 G/C gene polymorphisms and strength-related traits in 457 middle school-age children (219 boys and 238 girls; aged 11 ± 0.4 years). The assessment of different phenotypes was conducted with a number of performance tests. Gene polymorphisms were determined by PCR. The ACE D allele was associated with high results of standing long-jump test in boys [II 148.3 (16.3) cm, ID 152.6 (19.6) cm, DD 158.2 (19.1) cm; P = 0.037]. The ACTN3 R allele was associated with high results of performance tests in males only in combination with other genes (standing long-jump test: P = 0.021; handgrip strength test: P < 0.0001). Furthermore, the male carriers of the PPARA gene C allele demonstrated the best results of handgrip strength testing than GG homozygotes [GG 14.6 (4.0) kg, GC/CC 15.7 (4.3) kg; P = 0.048]. Thus, the ACE, ACTN3 and PPARA gene variants are associated with strength-related traits in physically active middle school-age boys.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Ahmetov II, Rogozkin VA. Genes, athlete status and training—an overview. Med Sport Sci. 2009;54:43–71. doi: 10.1159/000235696. - DOI - PubMed
    1. Bray MS, Hagberg JM, Pérusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2006–2007 update. Med Sci Sports Exer. 2009;41:35–73. - PubMed
    1. Thomis MA, Beunen GP, Van Leemputte M, Maes HH, Blimkie CJ, Claessens AL, Marchal G, Willems E, Vlietinck RF. Inheritance of static and dynamic arm strength and some of its determinants. Acta Physiol Scand. 1998;163:59–71. doi: 10.1046/j.1365-201x.1998.00344.x. - DOI - PubMed
    1. Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P, Thomis MA. ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics. 2007;32:58–63. doi: 10.1152/physiolgenomics.00173.2007. - DOI - PubMed
    1. Hughes DC, Day SH, Ahmetov II, Williams AG. Genetics of muscle strength and power: polygenic profile similarity limits skeletal muscle performance. J Sports Sci. 2011;29:1425–1434. doi: 10.1080/02640414.2011.597773. - DOI - PubMed

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