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Review
. 2012 Oct;3(10):739-54.
doi: 10.1007/s13238-012-2072-z. Epub 2012 Sep 15.

Aptamer-based molecular imaging

Tianjiao Wang  1 , Judhajeet Ray
Affiliations
Review

Aptamer-based molecular imaging

Tianjiao Wang et al. Protein Cell. 2012 Oct.

Abstract

Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms. Aptamers, short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically, are ideal molecular recognition elements for probe development in molecular imaging. This review summarizes the current state of aptamer-based biosensor development (probe design and imaging modalities) and their application in imaging small molecules, nucleic acids and proteins mostly in a cellular context with some animal studies. The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.

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