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Randomized Controlled Trial
. 2012 Nov;27(7):483-9.
doi: 10.1177/1533317512459794. Epub 2012 Sep 13.

From Alzheimer's disease retrogenesis: a new care strategy for patients with advanced dementia

Massimo Venturelli  1 , Alessandra Magalini, Renato Scarsini, Federico Schena
Affiliations
Randomized Controlled Trial

From Alzheimer's disease retrogenesis: a new care strategy for patients with advanced dementia

Massimo Venturelli et al. Am J Alzheimers Dis Other Demen. 2012 Nov.

Abstract

There is evidence that exercise may reduce the progressive cognitive dysfunction of Alzheimer's disease (AD). However, no previous investigation has studiethe acute effects of adapted games (AG) on patients with AD. The aim of this study was to examine the acute effects of AG on the agitated behavior (rating scale Agitated Behavior Rating Scale [ABRS]) and cognitive performance (Test for Severe Impairment [TSI]) of patients with advanced dementia. Twenty patients (83±4 yrs) participated in AG and placebo activities (PL). Agitated behavior and cognitive performance were compared before and after 30 minutes of AG and PL. In the hour after the AG, agitated behavior decreased by ∼4 ABRS points and cognitive performance increased by ∼5 TSI points. On the contrary, after PL we found no change in agitated behavior or cognitive performance. Our data indicate that AG can momentarily reduce agitated behavior and increase the cognitive performance in participants with AD.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Study overview.
Figure 2.
Figure 2.
Individual and Group mean Test for Severe Impairment. TSI indicates test for severe impairment. Open circles represent individual TSI score before and after the first ball games (adapted games [AG]), open triangles represent individual TSI score before and after the second AG session. Open squares represent group mean of TSI before and after AG. Filled circles represent individual TSI score before and after the first placebo exercise (PL), filled triangles represent individual TSI score before and after the second PL activity. Filled squares represent group mean of TSI before and after PL. Group means are mean ± standard deviation (SD). *between-groups p < .05.
Figure 3.
Figure 3.
Number of errors on the 6 subscale cognitive domains of TSI. Data expressed as mean ± standard deviation (SD). * in-group and between groups p < .05.
See this image and copyright information in PMC

References

    1. Reisberg B, Franssen EH, Souren LE, Auer SR, Akram I, Kenowsky S. Evidence and mechanisms of retrogenesis in Alzheimer's and other dementias: management and treatment import. Am J Alzheimers Dis Other Demen. 2002;17(4):202–212. - PMC - PubMed
    1. Reisberg B, Franssen EH, Souren LE, Auer S, Kenowsky S. Progression of Alzheimer's disease: variability and consistency: ontogenic models, their applicability and relevance. J Neural Transm Suppl. 1998;54:9–20. - PubMed
    1. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139(9):1136–1139. - PubMed
    1. Taft LB. Conceptual analysis of agitation in the confused elderly. Arch Psychiatr Nurs. 1989;3(2):102–107. - PubMed
    1. Luo H, Lin M, Castle N. Physical restraint use and falls in nursing homes: a comparison between residents with and without dementia. Am J Alzheimers Dis Other Demen. 2011;26(1):44–50. - PMC - PubMed

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