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Comment
. 2012 Sep 25;109(39):15537-8.
doi: 10.1073/pnas.1213503109. Epub 2012 Sep 14.

Looking beyond overnutrition for causes of epidemic metabolic disease

Leonid Poretsky  1
Affiliations
Comment

Looking beyond overnutrition for causes of epidemic metabolic disease

Leonid Poretsky. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Traditional view (green) of the pathogenesis of diabetes mellitus describes a combination of genetic and environmental factors leading to obesity, insulin resistance, reduced insulin secretion, and hyperglycemia. A more recent approach includes a proinflammatory state contributing to insulin resistance (yellow). The current hypothesis also includes the effects of AGEs (red), which induce a proinflammatory state, increase adiposity, induce insulin resistance, and inhibit insulin secretion (details and references are provided in main text).
See this image and copyright information in PMC

Comment on

References

    1. Zajac J, Shrestha A, Patel P, Poretsky L. The main events in the history of diabetes mellitus. In: Poretsky L, editor. Principles of Diabetes Mellitus. New York: Springer; 2010. pp. 3–16.
    1. International Diabetes Federation (2011) IDF Diabetes Atlas. Brussels, Belgium: International Diabetes Federation. 5th ed. Available at www.idf.org/diabetesatlas.
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    1. Cai W, et al. 2012. Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. Proc Natl Acad Sci USA 109:15888–15893.
    1. Manning AK, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012;44:659–669. - PMC - PubMed

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