Quality of Liver and Kidney Function Tests among Public Medical Laboratories in Western Region of Amhara National Regional State of Ethiopia

Abstract

Background: Medical laboratories play essential roles in measurements of substances in body fluids for the purpose of diagnosis, treatment, prevention, and for greater understanding of the disease process. Thus, data generated from have to be reliable for which strict quality control, management and assurance are maintained. The aim of this study is to assess the accuracy and precision of clinical chemistry laboratories in western region of Amhara national regional state of Ethiopia in testing liver and kidney functions.

Methods: Eight laboratories in hospitals and a Regional Health Research Laboratory Center participated in this study from February to March, 2011. Each participant was requested to measure six specimens for six chemistry tests from two control samples. Three hundred twenty four test results to be reported from all participant laboratories, if all measurements can be made, were designed to be collected and statistically evaluated.

Results: None of the study subject laboratories could deliver all the six tests for estimation of both liver and renal functions simultaneously during the study period. Only 213 values from the expected 324 values were reported and about 65 % of the 213 values reported fell outside of the allowable limits of errors for the chemistry tests of the control specimen used.

Conclusion: This study finding showed that there were lack of accuracy and precision in chemistry measurements. A regular survey on medical laboratories should be conducted questioning the accuracy and precision of their analyses in order to sustain improvements in the quality of services provided by participating laboratories for the benefit of patients. Laboratory Quality Management Systems appreciate the need for regular quality control and quality assessment schemes in medical laboratories.

Keywords: Clinical Chemistry Tests; External Quality Assessment; Laboratory Medicine.

Figure 1

Plot of sample SGOT/AST (A) in Hematrol N values versus sample SGOT/AST (B) in Hematrol P values, Bahirdar, 2011.

Figure 2

Plot of sample SGPT/ALT (A) in Hematrol N values versus sample SGPT/ALT (B) in Hematrol P values. Bahir Dar, 2011.

Figure 3

Plot of sample ALP (A) in Hematrol N values versus sample ALP (B) in Hematrol P values, Bahir Dar, 2011.