Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Sep;1(1):20-4.
doi: 10.1007/s13555-011-0005-z. Epub 2011 Aug 22.

Erosive lichen planus of the soles: Effective response to prednisone

Affiliations

Erosive lichen planus of the soles: Effective response to prednisone

Samia Goucha et al. Dermatol Ther (Heidelb). 2011 Sep.

Abstract

Background: Erosive lichen planus (LP) of the soles is a rare variant of LP, characterized by chronic, painful, and disabling plantar ulcerations. Herein, we report a case with complete healing following treatment with systemic steroids.

Case report: A 38-year-old woman was referred with painful and disabling erosive bilateral plantar LP, which she had experienced for 6 weeks. A 1 mg/kg/day, oral prednisone therapy led to rapid improvement and complete healing within 3 weeks, with a sustained result under a low dose maintenance therapy.

Discussion: Ulcerative plantar LP is significantly known to be unresponsive to several topical and systemic therapies. Surgical excision and grafting is the treatment of choice. Systemic steroids are reported to have inefficient or partial results; both on cutaneous healing and on maintenance of the result. Our patient achieved complete cicatrisation with a sustained result of 3 months under a low dose of prednisone (5 mg/day).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Bilateral erosions on internal plantar archs
Figure 2
Figure 2
Longitudinal melanonychia of toenails
Figure 3
Figure 3
Epidermal hyperplasia, elongated rete ridges, and bandlike lymphocytic infiltration in the superficial dermal area
Figure 4
Figure 4
Complete healing of the erosions within 3 weeks under systemic steroids

References

    1. Schepis C., Lentini M., Siragusa M. Erosive lichen planus on an atypical site mimicking a facticial dermatitis. Acta Derm Venereol. 2010;90:185–186. doi: 10.2340/00015555-0809. - DOI - PubMed
    1. Salavastru C., Tiplica G.S. Therapeutic hotline: ulcerative lichen planus. Treatment challenges. Dermatol Ther. 2010;23:203–205. doi: 10.1111/j.1529-8019.2010.01316.x. - DOI - PubMed
    1. Al-Khenaizan S., Al-Mubarak L. Ulcerative lichen planus of the sole: excellent response to topical tacrolimus. Int J Dermatol. 2008;47:626–628. doi: 10.1111/j.1365-4632.2008.03545.x. - DOI - PubMed
    1. Patrone P., Stinco G., La Pia E., Frattasio A., De Francesco V. Surgery and cyclosporine A in the treatment of erosive lichen planus of the feet. Eur J Dermatol. 1998;8:243–244. - PubMed
    1. Wollina U., Konrad H., Graefe T. Ulcerative lichen planus: a case responding to Recombinant Platelet-derived Growth Factor BB and immunosuppression. Acta Derm Venereol. 2001;81:364–383. doi: 10.1080/000155501317140115. - DOI - PubMed

LinkOut - more resources