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. 2013 Apr;68(4):412-8.
doi: 10.1093/gerona/gls191. Epub 2012 Sep 17.

Motoric cognitive risk syndrome and the risk of dementia

Joe Verghese  1 , Cuiling Wang, Richard B Lipton, Roee Holtzer
Affiliations

Motoric cognitive risk syndrome and the risk of dementia

Joe Verghese et al. J Gerontol A Biol Sci Med Sci. 2013 Apr.

Abstract

Background: Despite growing evidence of links between gait and cognition in aging, cognitive risk assessments that incorporate motoric signs have not been examined. We sought to validate a new Motoric Cognitive Risk (MCR) syndrome to identify individuals at high risk of developing dementia.

Methods: We evaluated 997 community residing individuals aged 70 and older participating in the Einstein Aging Study over a median follow-up time of 36.9 months. MCR syndrome was defined as presence of cognitive complaints and slow gait (one standard deviation below age- and sex-specific gait speed means) in nondemented individuals. Cox models were used to evaluate the effect of MCR syndrome on the risk of developing dementia and subtypes.

Results: Fifty-two participants met criteria for MCR syndrome at baseline with a prevalence of 7% (95% CI: 5-9%). Prevalence of MCR increased with age. Participants with MCR were at higher risk of developing dementia (hazard ratio [HR] adjusted for age, sex, and education: 3.27, 95% CI: 1.55-6.90) and vascular dementia (adjusted HR: 12.81, 95% CI: 4.98-32.97). The association of MCR with risk of dementia or vascular dementia remained significant even after accounting for other confounders and diagnostic overlap with "cognitive" mild cognitive impairment syndrome subtypes.

Conclusions: A motor-based MCR syndrome provides a clinical approach to identify individuals at high risk for dementia, especially vascular dementia, to target for further investigations and who may benefit from preventive interventions.

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Figures

Figure 1.
Figure 1.
Survival plots show the cumulative risk of developing any dementia (A) and vascular dementia (VaD) (B) based on baseline motoric cognitive risk (MCR) syndrome status.
See this image and copyright information in PMC

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References

    1. Rosano C, Brach J, Longstreth Jr WT, Newman AB. Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults. Neuroepidemiology. 2006; 26: 52–60 - PubMed
    1. Verghese J, Derby C, Katz MJ, Lipton RB. High risk neurological gait syndrome and vascular dementia. J Neural Transm. 2007; 114: 1249–1252 - PubMed
    1. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ, Buschke H. Abnormality of gait as a predictor of non-Alzheimer’s dementia. N Engl J Med. 2002; 347: 1761–1768 - PubMed
    1. McGinn AP, Kaplan RC, Verghese J, et al. Walking speed and risk of incident ischemic stroke among postmenopausal women. Stroke. 2008; 39: 1233–1239 - PubMed
    1. Verghese J, Wang C, Lipton RB, Holtzer R, Xue X. Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatr. 2007; 78: 929–935 - PMC - PubMed

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