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Review
. 2012 Oct;13(10):932-8.
doi: 10.1038/ni.2422. Epub 2012 Sep 18.

The price of immunity

Romina S Goldszmid  1 , Giorgio Trinchieri
Affiliations
Review

The price of immunity

Romina S Goldszmid et al. Nat Immunol. 2012 Oct.

Abstract

Resistance mechanisms of the innate and adaptive immune responses prevent the colonization of foreign organisms in unwanted anatomical sites and participate in tissue repair and restoration of homeostasis after damage induced either by the invasion of pathogenic microbes or by the organism's response to them. The intensity of the response is controlled and limited by positive and negative feedback circuits that aim at preventing collateral tissue damage. In this Review we will discuss the protective and pathogenic effects of host-commensal microbiota mutualism on the immune response and illustrate some examples of collateral tissue and systemic damage caused by immunity to pathogens.

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References

    1. Nat Genet. 2008 Aug;40(8):955-62 - PubMed
    1. J Exp Med. 2010 May 10;207(5):1045-56 - PubMed
    1. J Gen Virol. 2005 Jul;86(Pt 7):1885-1890 - PubMed
    1. Immunol Rev. 2008 Dec;226:147-59 - PubMed
    1. Nat Med. 2006 Dec;12(12):1365-71 - PubMed

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