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Review
. 2012 Oct;92(4):414-7.
doi: 10.1038/clpt.2012.96.

Pharmacogenomics knowledge for personalized medicine

M Whirl-Carrillo  1 , E M McDonagh, J M Hebert, L Gong, K Sangkuhl, C F Thorn, R B Altman, T E Klein
Affiliations
Review

Pharmacogenomics knowledge for personalized medicine

M Whirl-Carrillo et al. Clin Pharmacol Ther. 2012 Oct.

Abstract

The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene-drug associations and genotype-phenotype relationships. Curators assign levels of evidence to variant-drug associations using well-defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high-quality information supporting personalized medicine-implementation projects.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
The PharmGKB Knowledge Pyramid. CPIC, Clinical Pharmacogenetics Implementation Consortium; NLP, natural-language processing. From PharmGKB with the permission of PharmGKB and Stanford University. Copyright PharmGKB.
See this image and copyright information in PMC

References

    1. McDonagh EM, Whirl-Carrillo M, Garten Y, Altman RB, Klein TE. From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. Biomark Med. 2011;5:795–806. - PMC - PubMed
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    1. Johnson JA, Burkley BM, Langaee TY, Clare-Salzler MJ, Klein TE, Altman RB. Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array. Clin Pharmacol Ther. 2012;92:437–439. - PMC - PubMed
    1. Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin Pharmacol Ther. 2011;89:464–467. - PMC - PubMed

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