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Editorial
. 2012 Dec 1;303(11):C1125-6.
doi: 10.1152/ajpcell.00301.2012. Epub 2012 Sep 19.

Intoxicated Na(+) channels. Focus on "ethanol stimulates epithelial sodium channels by elevating reactive oxygen species"

Peter M Snyder
Editorial

Intoxicated Na(+) channels. Focus on "ethanol stimulates epithelial sodium channels by elevating reactive oxygen species"

Peter M Snyder. Am J Physiol Cell Physiol. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Model of epithelial sodium channel (ENaC) regulation by ethanol and reactive oxygen species (ROS). Ethanol and a variety of other stimuli increase intracellular ROS. By activating phosphatidylinositol 3-kinase (PI3K), this increases phosphatidylinositol 3,4,5-trisphosphate (PIP3). Previous work indicates that PIP3 enhances ENaC gating and cell surface abundance, resulting in increased Na+ absorption.
See this image and copyright information in PMC

Comment on

References

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