[Brugada syndrome]

Abstract

Brugada syndrome is a rare, hereditary and primary electrical disease which is associated with a risk of syncope and sudden cardiac death. Initially, Brugada syndrome was considered to be a very malignant disease; however, in subsequent studies the risk of sudden death especially in asymptomatic patients was much lower than initially expected. In patients with Brugada type 1 electrocardiogram (ECG) findings and rhythmogenic syncope or sudden cardiac arrest, implantable cardioverter-defibrillator (ICD) implantation is indicated. Risk stratification and therapy in asymptomatic patients is controversially discussed and is clinically challenging. Due to the low event rate in asymptomatic patients with Brugada syndrome the identification of predictors of sudden cardiac death is difficult. Thus, risk stratification and therapy in asymptomatic patients has to be performed individually. This manuscript reviews the current data on diagnosis, risk stratification and therapy of Brugada syndrome.