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Review
. 2012 Sep;26(9):621-6.
doi: 10.1155/2012/137129.

Pregnancy following liver transplantation: review of outcomes and recommendations for management

Kuljit S Parhar  1 , Paul S Gibson, Carla S Coffin
Affiliations
Review

Pregnancy following liver transplantation: review of outcomes and recommendations for management

Kuljit S Parhar et al. Can J Gastroenterol. 2012 Sep.

Abstract
in English, French

Liver transplantation is considered to be the treatment of choice for end-stage liver disease and its success has led to an increase in the number of female liver transplant recipients who are of childbearing age. Several key issues that are noted when counselling patients who are considering pregnancy following liver transplantation include the optimal timing of pregnancy, optimal contraception methods and the management of immunosuppression during pregnancy. The present review summarizes the most recent literature so that the clinician may address these issues with their patient and enable them to make informed decisions about pregnancy planning. The authors review recent studies examining maternal and fetal outcomes, and the rates of complications including risk of graft rejection. Subsequently, the authors provide recommendations for counselling prospective mothers and the management of the pregnant liver transplant recipient.

La transplantation hépatique est considérée comme le traitement de première intention de l’insuffisance hépatique au stade terminal, et sa réussite a suscité une augmentation du nombre de femmes greffées du foie en âge de procréer. On constate plusieurs enjeux importants lorsqu’on conseille les patientes qui envisagent une grossesse après une transplantation hépatique, soit le moment optimal de la grossesse, les méthodes de contraception optimales et la prise en charge de l’immunosuppression pendant la grossesse. La présente analyse résume les documents scientifiques les plus récents sur le sujet, afin que le clinicien puisse aborder ces questions avec ses patientes et leur permettre de prendre des décisions éclairées en matière de planification de grossesse. Les auteurs ont analysé les récentes études sur les issues maternelles et fœtales, et le taux de complications, y compris le risque de rejet de la transplantation. Les auteurs ont ensuite fourni des recommandations au sujet des conseils aux mères prospectives et de la prise en charge de la transplantation hépatique des greffées.

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References

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