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Comment
. 2007 Sep 15;110(6):1711-2.
doi: 10.1182/blood-2007-06-096677.

Attractive shedding

Frank R DeLeo  1
Affiliations
Comment

Attractive shedding

Frank R DeLeo. Blood. .

Abstract

In this issue of Blood, Chalaris and colleagues show that ADAM17 regulates shedding of interleukin-6 receptor (IL-6R) by apoptotic neutrophils, a process critical for IL-6 trans-signaling in the switch from neutrophil to mononuclear leukocyte recruitment during the resolution of inflammation.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests. ■

Figures

None
IL-6 trans-signaling in the resolution of inflammation. The inflammatory response involves influx of polymorphonuclear leukocytes (PMNs or neutrophils). Phagocytosis of microbes and cell activation ultimately lead to PMN apoptosis (a-PMN), during which ADAM17 is activated to cleave IL-6R from the cell surface (shedding). IL-6 and soluble IL-6R derived from neutrophils signal recruitment of mononuclear phagocytes by IL-6 trans-signaling, possibly through endothelial cells. Phagocytosis of apoptotic neutrophils by mononuclear phagocytes, typically macrophages (Mφ), is a key step in the resolution of acute inflammation.
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References

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