Tetanus in Ethiopia: unveiling the blight of an entirely vaccine-preventable disease
- PMID: 22996275
- DOI: 10.1007/s11910-012-0314-3
Tetanus in Ethiopia: unveiling the blight of an entirely vaccine-preventable disease
Abstract
Today, tetanus exacts its toll only in resource-poor countries like Ethiopia. Agrarian rural life with limited vaccine typifies tetanus risk in Ethiopia where current tetanus control trends on expanding infant immunization and eliminating highly prevalent maternal and neonatal tetanus (MNT). Protection by infant tetanus immunization primers disappears within an average of 3 years, if not followed by boosters. Second-year of life, school-based, and universal 10-yearly tetanus immunizations need to be supplemented. Facility-based reviews in Ethiopia reveal a continued burden of tetanus at tertiary-level hospitals where ICU care is suboptimal. Quality of medical care for tetanus is low - reflected by high case-fatality-rates. Opportunities at primary-health-care-units (antenatal-care, family planning, abortion, wound-care, tetanus-survivors) need to be fully-utilized to expand tetanus immunization. Prompt wound-care with post-exposure prophylaxis and proper footwear must be promoted. Standard ICU care needs to exist. Realization of cold-chain-flexible, needle-less and mono-dose vaccine programs allow avoiding boosters, vaccine-refrigeration, and improve compliance.
Similar articles
-
The role of timely initiation of antenatal care on protective dose tetanus toxoid immunization: the case of northern Ethiopia post natal mothers.BMC Pregnancy Childbirth. 2018 Jun 15;18(1):235. doi: 10.1186/s12884-018-1878-y. BMC Pregnancy Childbirth. 2018. PMID: 29907139 Free PMC article.
-
Tetanus toxoid vaccine: elimination of neonatal tetanus in selected states of India.Hum Vaccin Immunother. 2012 Oct;8(10):1439-42. doi: 10.4161/hv.21145. Epub 2012 Aug 16. Hum Vaccin Immunother. 2012. PMID: 22894950 Free PMC article.
-
Control of neonatal tetanus in India.Indian Pediatr. 1984 Jul;21(7):515-9. Indian Pediatr. 1984. PMID: 6519778
-
Tetanus in developing countries: an update on the Maternal and Neonatal Tetanus Elimination Initiative.Vaccine. 2003 Jul 28;21(24):3442-5. doi: 10.1016/s0264-410x(03)00347-5. Vaccine. 2003. PMID: 12850356 Review.
-
Neonatal tetanus elimination in Pakistan: progress and challenges.Int J Infect Dis. 2012 Dec;16(12):e833-42. doi: 10.1016/j.ijid.2012.07.015. Epub 2012 Aug 30. Int J Infect Dis. 2012. PMID: 22940280 Review.
Cited by
-
A Novel High-Potency Tetanus Vaccine.mBio. 2020 Aug 11;11(4):e01668-20. doi: 10.1128/mBio.01668-20. mBio. 2020. PMID: 32788381 Free PMC article.
-
An unusual complication of the traditional treatment of a closed fracture - generalized tetanus: a case report.J Med Case Rep. 2017 Oct 24;11(1):298. doi: 10.1186/s13256-017-1477-y. J Med Case Rep. 2017. PMID: 29061192 Free PMC article.
-
Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein.Vaccine. 2022 Aug 19;40(35):5103-5113. doi: 10.1016/j.vaccine.2022.07.011. Epub 2022 Jul 22. Vaccine. 2022. PMID: 35871872 Free PMC article.
-
Clinical Profile and Outcome of Pediatrics Tetanus: The Experience of a Tertiary Hospital in Ethiopia.Ethiop J Health Sci. 2017 Sep;27(5):559-564. doi: 10.4314/ejhs.v27i5.14. Ethiop J Health Sci. 2017. PMID: 29217961 Free PMC article.
-
Clinical profile of tetanus patients attended at Felege Hiwot Referral Hospital, Northwest Ethiopia: a retrospective cross sectional study.Springerplus. 2016 Jun 27;5(1):892. doi: 10.1186/s40064-016-2592-8. eCollection 2016. Springerplus. 2016. PMID: 27386340 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical