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Comment
. 2012 Sep 20;120(12):2352-4.
doi: 10.1182/blood-2012-08-445239.

Stubborn Tregs limit T-cell therapy

Christopher A Klebanoff  1 , Luca Gattinoni
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Free article
Comment

Stubborn Tregs limit T-cell therapy

Christopher A Klebanoff et al. Blood. .
Free article

Abstract

In this issue of Blood, Baba and colleagues characterize a residual pool ofCD4+CD25+Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy (ACT) for the treatment of cancer.

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