SNARing platelet granule secretion
- PMID: 22996656
- DOI: 10.1182/blood-2012-07-442756
SNARing platelet granule secretion
Abstract
In this issue of Blood, Ye et al and Al Hawas et al clarify the roles of 2 key fusion proteins that regulate the agonist-stimulated release of bioactive factors from platelets, and thereby explain the defective hemostasis in patients with 2 rare genetic diseases.
Comment on
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Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.Blood. 2012 Sep 20;120(12):2484-92. doi: 10.1182/blood-2012-05-430603. Epub 2012 Jul 5. Blood. 2012. PMID: 22767500 Free PMC article.
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Munc18b/STXBP2 is required for platelet secretion.Blood. 2012 Sep 20;120(12):2493-500. doi: 10.1182/blood-2012-05-430629. Epub 2012 Jul 12. Blood. 2012. PMID: 22791290 Free PMC article.
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