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Randomized Controlled Trial
. 2013 May;24(5):1637-46.
doi: 10.1007/s00198-012-2143-2. Epub 2012 Sep 21.

Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial

K M Winters-Stone  1 , J Dobek, L M Nail, J A Bennett, M C Leo, B Torgrimson-Ojerio, S-W Luoh, A Schwartz
Affiliations
Randomized Controlled Trial

Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial

K M Winters-Stone et al. Osteoporos Int. 2013 May.

Abstract

Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.

Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.

Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).

Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck-POWIR, 0.004 ± 0.093 g/cm(2) vs. FLEX, -0.010 ± 0.089 g/cm(2); p < 0.01; spine-POWIR, -0.003 ± 0.114 g/cm(2) vs. FLEX, -0.020 ± 0.110 g/cm(2); p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p < 0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p < 0.03).

Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

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Conflict of interest statement

Conflicts of interest None

Figures

Fig. 1
Fig. 1
Participant flow through the trial
Fig. 2
Fig. 2
Change in femoral neck and spine bone mineral density (BMD) among participants ≥1 year postmenopausal and participants <1 year postmenopausal. Data presented as mean and standard errors are presented as positive or negative for clarity. *p<0.05, group × time interaction within each menopausal group
Fig. 3
Fig. 3
Percent change in body composition among women in POWIR who attended more than or equal to vs. lesser than the mean attendance for supervised classes. Data presented as mean ± SE. *p<0.05, group × time interaction
See this image and copyright information in PMC

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