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Comment
. 2012 Sep 20;75(6):935-8.
doi: 10.1016/j.neuron.2012.09.006.

Neurodegeneration: new road leads back to the synapse

Peter Heutink  1 , Matthijs Verhage
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Neurodegeneration: new road leads back to the synapse

Peter Heutink et al. Neuron. .
Free article

Abstract

Much of Parkinson's research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al. (2012) addressing the biological functions of the Parkinson's gene LRRK2 now identifies a presynaptic substrate, homing in on the idea that synapse loss might be a central early aspect of neurodegeneration.

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  • LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
    Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P. Matta S, et al. Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022. Neuron. 2012. PMID: 22998870

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