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Comment
. 2012 Sep 21;14(5):321.
doi: 10.1186/bcr3209.

New insights into signalling networks regulating breast cancer stem cells

Alexander Swarbrick, Roger J Daly
Comment

New insights into signalling networks regulating breast cancer stem cells

Alexander Swarbrick et al. Breast Cancer Res. .

Abstract

In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.

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References

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