Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov 1;20(21):6482-8.
doi: 10.1016/j.bmc.2012.08.041. Epub 2012 Aug 31.

1,3-Azoles from ortho-naphthoquinones: synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis

Kelly C G Moura  1 , Paula F Carneiro, Maria do Carmo F R Pinto, José A da Silva, Valéria R S Malta, Carlos A de Simone, Gleiston G Dias, Guilherme A M Jardim, Jéssica Cantos, Tatiane S Coelho, Pedro E Almeida da Silva, Eufrânio N da Silva Jr
Affiliations
Free article

1,3-Azoles from ortho-naphthoquinones: synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis

Kelly C G Moura et al. Bioorg Med Chem. .
Free article

Abstract

Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the compounds evaluated, fourteen presented MIC values in the range of 0.78 to 6.25 μg/mL against susceptible and resistant strains of M. tuberculosis. Five structures were solved by X-ray crystallographic analysis. These substances are promising antimycobacterial prototypes.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources