Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Mar;15(2):191-4.
doi: 10.1038/aja.2012.87. Epub 2012 Sep 24.

Endocrine disruptors and falling sperm counts: lessons learned or not!

Stephen Safe  1
Affiliations
Review

Endocrine disruptors and falling sperm counts: lessons learned or not!

Stephen Safe. Asian J Androl. 2013 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structures of diverse endocrine disruptors that modulate estrogen signaling. AHR, aryl hydrocarbon receptor; HPTE, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.
See this image and copyright information in PMC

References

    1. Safe S. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit Rev Toxicol. 1984;13:319–95. - PubMed
    1. Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs) Crit Rev Toxicol. 1990;21:51–88. - PubMed
    1. Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol. 1994;24:87–149. - PubMed
    1. Poland A, Glover E, Kende AS. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem. 1976;251:4936–46. - PubMed
    1. Poland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol. 1982;22:517–54. - PubMed

Substances

LinkOut - more resources