Pegylated interferon for the adjuvant treatment of melanoma: FDA approved, but what is its role?
- PMID: 23002125
- PMCID: PMC3481887
- DOI: 10.1634/theoncologist.2012-0368
Pegylated interferon for the adjuvant treatment of melanoma: FDA approved, but what is its role?
Abstract
The article by Herndon and colleagues on the approval of peginterferon-alfa-2b for the adjuvant treatment of patients with resected node-positive melanoma, published in this issue of The Oncologist, is examined, and the relevance of this therapy in clinical practice discussed.
Conflict of interest statement
Comment on
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U.S. Food and Drug Administration Approval: peginterferon-alfa-2b for the adjuvant treatment of patients with melanoma.Oncologist. 2012;17(10):1323-8. doi: 10.1634/theoncologist.2012-0123. Epub 2012 Sep 21. Oncologist. 2012. PMID: 23002124 Free PMC article. Clinical Trial.
References
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- Eggermont AM, Suciu S, MacKie R, et al. Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): Randomised controlled trial. Lancet. 2005;366:1189–1196. - PubMed
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- Eggermont AM, Suciu S, Santinami M, et al. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised phase III trial. Lancet. 2008;372:117–126. - PubMed
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- Hauschild A, Weichenthal M, Rass K, et al. Efficacy of low-dose interferon α2a 18 versus 60 months of treatment in patients with primary melanoma of ≥1.5 mm tumor thickness: Results of a randomized phase III DeCOG trial. J Clin Oncol. 2010;28:841–846. - PubMed
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