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. 2012 Sep;1(3):157-161.
doi: 10.1007/s13665-012-0019-8.

Antibody-Mediated Lung Transplant Rejection

Ramsey Hachem  1
Affiliations

Antibody-Mediated Lung Transplant Rejection

Ramsey Hachem. Curr Respir Care Rep. 2012 Sep.

Abstract

Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndrome. Furthermore, cases of acute antibody-mediated rejection resulting in severe allograft dysfunction have been reported, and these demonstrate that antibodies can directly injure the allograft. However, the incidence and toll of antibody-mediated rejection are unknown because there is no widely accepted definition and some cases may be unrecognized. Clearly, humoral immunity has become an important area for research and clinical investigation.

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Conflict of interest statement

Disclosure

No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
This transbronchial lung biopsy from a patient with acute antibody-mediated rejection illustrates alveolar septal neutrophilia (blue arrows) suspicious for capillaritis.
Figure 2
Figure 2
Another transbronchial lung biopsy from the same patient with acute antibody-mediated rejection demonstrates hemorrhage and focal fibrin deposition.
See this image and copyright information in PMC

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