Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;87(2):701-4.
doi: 10.1073/pnas.87.2.701.

Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests

J Ott  1 , S Bhattacharya, J D Chen, M J Denton, J Donald, C Dubay, G J Farrar, G A Fishman, D Frey, A Gal, et al.
Affiliations

Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests

J Ott et al. Proc Natl Acad Sci U S A. 1990 Jan.

Abstract

Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliably estimate their map location. Multilocus homogeneity tests furnished convincing evidence for the presence of two XLRP loci, the likelihood ratio being 6.4 x 10(9):1 in favor of two versus a single XLRP locus and gave accurate estimates for their map location. In 60-75% of the families, location of an XLRP gene was estimated at 1 centimorgan distal to OTC, and in 25-40% of the families, an XLRP locus was located halfway between DXS14 (p58-1) and DXZ1 (Xcen), with an estimated recombination fraction of 25% between the two XLRP loci. There is also good evidence for a third XLRP locus, midway between DXS28 (C7) and DXS164 (pERT87), supported by a likelihood ratio of 293:1 for three versus two XLRP loci.

PubMed Disclaimer

References

    1. J Med Genet. 1986 Dec;23(6):521-30 - PubMed
    1. Hum Genet. 1988 Jan;78(1):60-4 - PubMed
    1. Am J Hum Genet. 1988 Mar;42(3):498-505 - PubMed
    1. J Med Genet. 1988 Apr;25(4):222-6 - PubMed
    1. Genomics. 1988 Apr;2(3):263-6 - PubMed

Publication types

Substances