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Comparative Study
. 2012 Sep-Oct;18(5):327-33.
doi: 10.4103/1319-3767.101132.

Serum TGF-β, Serum MMP-1, and HOMA-IR as non-invasive predictors of fibrosis in Egyptian patients with NAFLD

Adel A Mahmoud  1 , Amal S Bakir, Sherif S Shabana
Affiliations
Comparative Study

Serum TGF-β, Serum MMP-1, and HOMA-IR as non-invasive predictors of fibrosis in Egyptian patients with NAFLD

Adel A Mahmoud et al. Saudi J Gastroenterol. 2012 Sep-Oct.

Abstract

Background/aim: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide. A number of these patients progress to nonalcoholic steatohepatitis (NASH) which carries significant morbidity and mortality. The aim of this study is to evaluate the diagnostic value of serum levels of transforming growth factor beta-1 (TGF-β1) matrix metalloproteinase-1 (MMP-1), and insulin resistance as predictors of fibrosis in Egyptian NAFLD patients.

Patients and methods: Fifty patients with NAFLD and different stages of fibrosis were studied. Serum levels of TGF-β1, MMP-1, and fasting serum insulin were measured; calculation of the homeostasis model assessment for insulin resistance (HOMA-IR) was done.

Results: TGF-β1 gives a sensitivity of 100% and specificity of 94.4% for stage 1 fibrosis, 100% and 93.9%, respectively, for stage 2 fibrosis, and 97.7% and 100%, respectively, for stage 3 fibrosis. MMP-1 showed sensitivity and specificity of 88% and 81.8%, respectively, for stage 2 fibrosis, 90.9% and 55.56%, respectively, for stage 3 fibrosis, but it is of no diagnostic value in stage 1 fibrosis.

Conclusion: Serum TGF-β1, MMP-1, and insulin resistance (HOMA-IR) proved to be potentially useful noninvasive markers in predicting fibrosis in NASH patients.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
ROC curves for HOMA-IR, MMP-1 and TGFβ1 for stage 1 fibrosis
Figure 2
Figure 2
ROC curves for HOMA-IR, MMP-1 and TGFβ1 for stage 2 fibrosis
Figure 3
Figure 3
ROC curves for HOMA-IR, MMP-1, TGFβ1 for stage 3 fibrosis
See this image and copyright information in PMC

References

    1. Dowman JK, Tomlinson JW, Newsome PN. Systematic review: The diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2011;33:525–40. - PMC - PubMed
    1. Ratziu V, Charlotte F, Heurtier A. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898–906. - PubMed
    1. Adams LA, Lymp JF, St Sauver J. The natural history of nonalcoholic fatty liver disease: A population-based cohort study. Gastroenterology. 2005;129:113–21. - PubMed
    1. Adams LA, Sanderson S, Lindor KD. The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies. J Hepatol. 2005;42:132–8. - PubMed
    1. Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets. J Cell Mol Med. 2006;10:76–99. - PMC - PubMed

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