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. 2012 Nov 5;8(11):598-600.
doi: 10.1038/nrneurol.2012.202. Epub 2012 Sep 25.

Alzheimer disease: from inherited to sporadic AD-crossing the biomarker bridge

Harald Hampel  1 , Simone Lista
Affiliations

Alzheimer disease: from inherited to sporadic AD-crossing the biomarker bridge

Harald Hampel et al. Nat Rev Neurol. .

Abstract

Whether dominantly inherited variants of Alzheimer disease (AD) and 'sporadic' forms exhibit similar pathophysiological and biomarker signatures remains unresolved. A landmark study has proposed a biomarker progression model of dominantly inherited AD, but a complex systems biology and physiology approach is required to translate these findings to sporadic disease.

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References

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