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Review
. 2012 Sep 25;79(13 Suppl 1):S207-12.
doi: 10.1212/WNL.0b013e31826959d2.

Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy

Vivek Misra  1 , Michael M Ritchie, Laura L Stone, Walter C Low, Vallabh Janardhan
Affiliations
Review

Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy

Vivek Misra et al. Neurology. .

Abstract

Objective: Cell-based therapies are being investigated as an adjunct to IV thrombolysis or mechanical thrombectomy in ischemic stroke. This review summarizes the potential applications as well as challenges of intravascular cell delivery in ischemic stroke.

Method: We conducted a search of Medline as well as the clinicaltrials.gov Web site for all ongoing human clinical studies using stem cells in ischemic stroke patients.

Result: The pros and cons of the various donor cell types and routes of cell delivery, including intravascular delivery, in ischemic stroke are discussed. In addition, the potential challenges in translation from bench to bedside, the optimal techniques for intravascular cell delivery, and an updated comprehensive list of ongoing clinical trials in ischemic stroke are highlighted.

Conclusions: Stem cells have shown a promising role in ischemic stroke, in preclinical studies as well as initial pilot studies. Further studies are needed to assess intravascular cell therapy as a potential adjunct to thrombolysis or mechanical thrombectomy in ischemic stroke.

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Figures

Figure
Figure. Phase contrast image of human umbilical cord blood stem cells
See this image and copyright information in PMC

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