Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:791765.
doi: 10.1155/2011/791765. Epub 2011 May 23.

Does the serum testosterone level have a relation to coronary artery disease in elderly men?

Mohamed A Helaly  1 , Eid Daoud, Noha El-Mashad
Affiliations

Does the serum testosterone level have a relation to coronary artery disease in elderly men?

Mohamed A Helaly et al. Curr Gerontol Geriatr Res. 2011.

Abstract

Background. The low serum level of testosterone in the elderly subjects may contribute to coronary artery disease (CAD). Our aim is to study serum levels of free testosterone in elderly men with CAD. Subjects and Methods. This study was conducted on 100 elderly males with CAD, one half of them was presented with ACS (with mean age 69.6 ± 2.44 year), and the other half was presented with stable CAD (with mean age 69.42 ± 2.14 year), in addition to 50 apparently healthy elderly males (with mean age 69.06 ± 1.64 year) as a control group. We detected the levels of serum free testosterone, cortisol, fibrinogen, plasminogen activator inhibitor-1(PAI-1), high sensitive C-reactive protein(hsCRP), interleukin-6(IL-6). Results. Cases with CAD had significant lower values of free testosterone and HDL-c, but they had significant higher values of cortisol, fibrinogen, PAI-1, IL-6, hsCRP, in comparison to control group. Cases with ACS had significant higher values of cortisol, hsCRP, IL-6, fibrinogen, PAI-1, total cholesterol and BMI more than those with stable CAD. The free testosterone had significant negative correlation with fibrinogen, PAI-1, hsCRP and IL-6 in both groups of patients. Conclusion. The lower value of serum free testosterone in elderly male subjects may contribute to CAD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation of free testosterone with hsCRP in patients with ACS (group 1).
Figure 2
Figure 2
Correlation of free testosterone with hsCRP in patients with stable CAD (group 2).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Glen SK, Boon NA. Coronary artery disease in the elderly. Reviews in Clinical Gerontology. 1999;9(1):13–21.
    1. Phillips GB, Pinkernell BH, Jing TY. The association of hypotestosteronemia with coronary artery disease in men. Arteriosclerosis and Thrombosis. 1994;14(5):701–706. - PubMed
    1. Rosano GMC, Sheiban I, Massaro R, et al. Low testosterone levels are associated with coronary artery disease in male patients with angina. International Journal of Impotence Research. 2007;19(2):176–182. - PubMed
    1. Yeap BB, Hyde Z, Almeida OP, et al. Lower testosterone levels predict incident stroke and transient ischemic attack in older men. Journal of Clinical Endocrinology and Metabolism. 2009;94(7):2353–2359. - PubMed
    1. Braunwald E. Unstable angina. A classification. Circulation. 1989;80(2):410–414. - PubMed