Morbidity and mortality of diabetic ketoacidosis with and without insulin pump care
- PMID: 23009106
- DOI: 10.1089/dia.2012.0161
Morbidity and mortality of diabetic ketoacidosis with and without insulin pump care
Abstract
Diabetic ketoacidosis (DKA) is one of the most common, costly, and dangerous acute complications in people with type 1 diabetes (T1D). Although DKA has been reported to occur with less frequency than severe hypoglycemia, it is associated with a higher mortality rate and is the leading cause of diabetes-related deaths in children and adolescents. The most common risk factor for DKA is lack of adherence to insulin treatment. Other factors include underinsurance, psychiatric disorders, occlusion of insulin pump infusion sets, and illness. It has been suggested that use of continuous subcutaneous insulin infusion therapy may increase the risk for DKA, although clinical trials have not supported this claim. Expert care within a T1D specialty clinic may help reduce the risk of DKA mortality. Further advances are needed in developing new technologies and methods to improve glycemic control in intensively treated patients without increasing the risk of acute complications. The purpose of this review is to discuss DKA morbidity and mortality in youth with T1D, particularly in relation to insulin pump use.
Comment in
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New technologies and old challenges in type 1 diabetes.Diabetes Technol Ther. 2012 Dec;14(12):1082-3. doi: 10.1089/dia.2012.0294. Diabetes Technol Ther. 2012. PMID: 23216337 No abstract available.
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Possibility to reduce mortality in diabetic ketoacidosis.Diabetes Technol Ther. 2013 Sep;15(9):786. doi: 10.1089/dia.2013.0121. Epub 2013 Aug 9. Diabetes Technol Ther. 2013. PMID: 23931740 No abstract available.
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Possibility to reduce diabetic ketoacidosis-related mortality in type 1 diabetes: prevention versus treatment.Diabetes Technol Ther. 2013 Sep;15(9):787. doi: 10.1089/dia.2013.0124. Epub 2013 Aug 9. Diabetes Technol Ther. 2013. PMID: 23931741 No abstract available.
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