Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Sep 24;16(5):158.
doi: 10.1186/cc11482.

Measuring glomerular filtration rate in acute kidney injury: yes, but not yet

Bruce A Molitoris
Comment

Measuring glomerular filtration rate in acute kidney injury: yes, but not yet

Bruce A Molitoris. Crit Care. .

Abstract

Acute kidney injury has become a major focus for nephrologists and critical care physicians. The development of structural biomarkers is proceeding, but the results to date have been disappointing. The use of a shortened creatinine clearance as a functional acute kidney injury biomarker is not new but has not been compared with that of other diagnostic approaches. A rapid, repeatable, and accurate measured glomerular filtration rate would be the gold standard for a functional biomarker and is not far off.

PubMed Disclaimer

Comment on

References

    1. Pickering JW, Frampton CM, Walker RJ, Shaw GM, Endre ZH. Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients. Crit Care. 2012;16:R107. doi: 10.1186/cc11391. - DOI - PMC - PubMed
    1. Hewitt SM, Dear J, Star RA. Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol. 2004;16:1677–1689. doi: 10.1097/01.ASN.0000129114.92265.32. - DOI - PubMed
    1. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004;16:13368–13373. doi: 10.1073/pnas.0403453101. - DOI - PMC - PubMed
    1. Herget-Rosenthal S, Kribben A, Pietruck F, Ross B, Philipp T. Two by two hour creatinine clearance--repeatable and valid. Clin Nephrol. 1999;16:348–354. - PubMed
    1. Cherry RA, Eachempati SR, Hydo L, Barie PS. Accuracy of short-duration creatinine clearance determinations in predicting 24-hour creatinine clearance in critically ill and injured patients. J Trauma. 2002;16:267–271. doi: 10.1097/00005373-200208000-00013. - DOI - PubMed