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. 2012 Aug;10(8):1662-1670.
doi: 10.3390/md10081662. Epub 2012 Aug 10.

Briareolate esters from the gorgonian Briareum asbestinum

Rian J Meginley  1 , Prasoon Gupta  1 , Thomas C Schulz  2 , Amanda B McLean  3 , Allan J Robins  2 , Lyndon M West  1
Affiliations

Briareolate esters from the gorgonian Briareum asbestinum

Rian J Meginley et al. Mar Drugs. 2012 Aug.

Abstract

Two new briarane diterpenoids briareolate esters J (1) and K (2) were isolated from the methanolic extract of the octocoral Briareum asbestinum collected off the coast of Boca Raton, Florida. The structures of briaranes 1 and 2 were elucidated by interpretation of spectroscopic data. Briareolate ester K (2) showed weak growth inhibition activity against human embryonic stem cells (BG02).

Keywords: Briareum asbestinum; briarane; briareolate ester; human embryonic stem cell; octocoral.

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Figures

Figure 1
Figure 1
HPLC chromatogram of the pre-fractionated extract of B. asbestinum showing the fractions separated using ELSD-directed collection to generate a semi-purified extract library for biological screening.
Figure 2
Figure 2
A cell index vs. time plot for a pre-fractionated extract library of B. asbestinum against the BG02 cell line. A drop in cell index within the first 24–48 h after addition of the compounds is interpreted as toxicity or induction of apoptosis.
Figure 3
Figure 3
Structures of compounds 1–7.
Figure 4
Figure 4
Briareum asbestinum.
Figure 5
Figure 5
Selected 2D NMR correlations for briareolate ester J (1).
Figure 6
Figure 6
Selected NMR correlations for briareolate ester K (2).
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