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. 2012 Sep 27;17(10):11484-94.
doi: 10.3390/molecules171011484.

The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR

Kang In Choe  1 , Joo Hee Kwon, Kwan Hee Park, Myeong Hwan Oh, Manh Heun Kim, Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha, Min Won Lee
Affiliations

The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR

Kang In Choe et al. Molecules. .

Abstract

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.

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Figures

Figure 1
Figure 1
Chemical structures of compounds 1-8 isolated from RRS.
Figure 2
Figure 2
HPLC chromatograms of RRS extracts.
See this image and copyright information in PMC

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