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. 2012:2012:940580.
doi: 10.1155/2012/940580. Epub 2012 Sep 17.

Morbidity and Mortality Patterns of Hospitalised Adult HIV/AIDS Patients in the Era of Highly Active Antiretroviral Therapy: A 4-year Retrospective Review from Zaria, Northern Nigeria

Dimie Ogoina  1 , Reginald O Obiako, Haruna M Muktar, Mukhtar Adeiza, Aliyu Babadoko, Abdulaziz Hassan, Isa Bansi, Henry Iheonye, Matthew Iyanda, Eric Tabi-Ajayi
Affiliations

Morbidity and Mortality Patterns of Hospitalised Adult HIV/AIDS Patients in the Era of Highly Active Antiretroviral Therapy: A 4-year Retrospective Review from Zaria, Northern Nigeria

Dimie Ogoina et al. AIDS Res Treat. 2012.

Abstract

Background. This study, undertaken in major tertiary hospital in northern Nigeria, examined the morbidity and mortality patterns of hospitalised adult HIV/AIDS patients in the HAART era. Methods. Between January 2006 and December 2009, admission records and causes of deaths of hospitalised medical HIV-infected patients were retrieved and analysed according to antiretroviral (ART) status. Results. Of the 207 HIV/AIDS patients reviewed, majority were newly diagnosed (73.4%), and most were hospitalised and died from various AIDS-defining illnesses, mainly disseminated tuberculosis and sepsis. Immune-inflammatory-reconstitution-syndrome, ART-toxicity and ART-failure, contributed to morbidity and mortality in patients receiving ART. Sixty six (31.9%) patients died, with higher mortality in males and in those with lower CD4-cell count, lower PCV, and shorter hospital stay. However, hospital stay ≤3 days and severe anaemia (PCV < 24%) were independent predictors of mortality. Conclusion. In the current HAART era, late presentation and tuberculosis continue to fuel the HIV/AIDS pandemic in Africa, with emerging challenges due to ART-related complications.

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Figures

Figure 1
Figure 1
Survival after hospitalisation in relation to antiretroviral status—no significant difference in survival rates were observed between both ART groups (Log rank P = 0.65, Breslow P = 0.44). Survival rates dropped sharply in both ART groups within the first 10 days of hospitalisation.
See this image and copyright information in PMC

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