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Clinical Trial
. 2013 Jan;166(1):10-3.
doi: 10.1016/j.ejogrb.2012.09.006. Epub 2012 Sep 27.

Cell-free fetal DNA and adverse outcome in low risk pregnancies

Werner Stein  1 , Sina Müller, Kai Gutensohn, Günter Emons, Tobias Legler
Affiliations
Clinical Trial

Cell-free fetal DNA and adverse outcome in low risk pregnancies

Werner Stein et al. Eur J Obstet Gynecol Reprod Biol. 2013 Jan.

Abstract

Objective: To analyze in a large prospective cohort study of low risk pregnancies whether cell-free fetal (cff) DNA in maternal plasma of the second trimester might be associated with the development of preeclampsia, preterm delivery, and small for gestational age.

Study design: A subset of a large prospective cohort study in serological RhD negative pregnant women with RHD positive fetuses was used. Cff DNA was determined through the detection of RHD specific sequences with real-time PCR.

Results: In 611 pregnancies, rates of 7.2% preeclampsia, 1.6% preterm birth ≤32, 2.9% ≤34, and 12.4% ≤37 weeks of gestation, 5.7% of small for gestational age <5th percentile, and 8.2% <10th percentile were observed. For none of these risk groups an association with cff DNA could be established.

Conclusion: Cff DNA in maternal plasma of the second trimester was not found to be a marker for an adverse pregnancy outcome in low risk pregnancies.

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