All things to all people
- PMID: 23021211
- DOI: 10.1016/j.cell.2012.09.006
All things to all people
Abstract
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Transcriptional amplification in tumor cells with elevated c-Myc.Cell. 2012 Sep 28;151(1):56-67. doi: 10.1016/j.cell.2012.08.026. Cell. 2012. PMID: 23021215 Free PMC article.
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c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.Cell. 2012 Sep 28;151(1):68-79. doi: 10.1016/j.cell.2012.08.033. Cell. 2012. PMID: 23021216 Free PMC article.
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