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Review
. 2012 Dec;40(12):967-73.
doi: 10.1016/j.exphem.2012.09.010. Epub 2012 Sep 26.

Higher-order orchestration of hematopoiesis: is cohesin a new player?

Anil K Panigrahi  1 , Debananda Pati
Affiliations
Review

Higher-order orchestration of hematopoiesis: is cohesin a new player?

Anil K Panigrahi et al. Exp Hematol. 2012 Dec.

Abstract

Hematopoiesis-the process that generates distinct lineage-committed blood cells from a single multipotent hematopoietic stem cell-is a complex process of cellular differentiation regulated by a set of dynamic transcriptional programs. Cytokines and growth factors, transcription factors, chromatin remodeling, and modifying enzymes have been suggested to enact critical roles during hematopoiesis, leading to the development of myeloid, lymphoid, erythroid and platelet precursors. How is such a complex process orchestrated? Is there a higher order of hematopoiesis regulation? These are some of the unresolved questions in the field of hematopoiesis. Here, we suggest that cohesin, which is known to mediate chromosomal cohesion between sister chromatids, may have a central role in the orchestration of hematopoiesis and serve as a master transcriptional regulator.

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Figures

Figure 1
Figure 1
A schematic of hematopoietic differentiation. The solid curved arrow represents higher potential of self-renewal of LT-HSCs. This schematic merges several models as discussed in references 2, , –. LT-HSC=Long-term HSC; ST-HSC=short-term HSC; CMP=common myeloid progenitor; LMPP=lymphoid-primed MPP; ETP=early T-lineage progenitor; MEP=megakaryocyte-erythrocyte progenitor; GMP=granulocyte-monocyte progenitor; CLP=common lymphoid progenitor; Ery=erythrocyte; Mka=megakaryocyte; Gra=granulocyte; Mac= macrophage; Neu=neutrophil; Eos=eosinophil; Den=dendritic cell; B=B-cells; T=T-cells; NK=natural killer cells.
Figure 2
Figure 2
Cohesin as a master-regulator of transcription and chromatin reconfiguration. Apart from ensuring sister chromatid cohesion, cohesin cooperates with CTCF to effectuate transcriptional insulation, forms looping of chromatin to bring enhancers and promoters closer, recruits the mediator complex to support establishment of the pre-initiation complex (PIC), interacts with and recruits tissue- and signal-specific TFs, and interacts with chromatin remodeling (CR) and chromatin modifying (CM) enzymes to possibly recruit these activities to the promoter to support transcription.
See this image and copyright information in PMC

References

    1. Orkin SH, Zon LI. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 2002;3:323–328. - PubMed
    1. Seita J, Weissman IL. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med. 2010;2:640–653. - PMC - PubMed
    1. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A. 1994;91:9857–9860. - PMC - PubMed
    1. Abkowitz JL, Catlin SN, McCallie MT, Guttorp P. Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. Blood. 2002;100:2665–2667. - PubMed
    1. Brown G, Hughes PJ, Ceredig R, Michell RH. Versatility and nuances of the architecture of haematopoiesis—Implications for the nature of leukaemia. Leuk Res. 2012;36:14–22. - PubMed

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