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Review
. 2013 Feb;6(1):228-37.
doi: 10.1161/CIRCEP.111.962050. Epub 2012 Sep 28.

Dilated cardiomyopathy

Neal K Lakdawala  1 , Jeffery R Winterfield, Birgit H Funke
Affiliations
Review

Dilated cardiomyopathy

Neal K Lakdawala et al. Circ Arrhythm Electrophysiol. 2013 Feb.
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: None

Figures

Figure 1
Figure 1
Inheritance and Expression Patterns in Familial DCM. Disease transmission from father to son supports autosomal dominant inheritance (arrow). Incomplete penetrance is demonstrated by individual A, who has no evidence of DCM but is an obligate carrier of a disease variant by virtue of having an affected father and son. Variable clinical expression is evident with clinical manifestations differing amongst affected individuals within the kindred, which may obscure recognition of shared genetic disease. In this family, the presence of arrhythmias, conduction disease and DCM are consistent with disease caused by a mutation in LMNA, which was subsequently identified in individual B. Black symbols = clinically affected individuals; white symbols = clinically unaffected individuals; circle=female; square=male; slash=deceased. + = LMNA mutation positive; − = LMNA mutation negative; AF = atrial fibrillation; AVB = atrioventricular block; LVEF = left ventricular ejection fraction; SCD = sudden cardiac death.
Figure 2
Figure 2
Non-Coronary Pattern of Delayed Gadolinium Enhancement imaged with Cardiac MRI in Familial DCM. Short axis Cardiac MRI (CMR) images reveal circumferential subepicardial delayed enhancement (DE) of gadolinium (arrows) in a young patient with familial DCM and palmoplantar keratoderma caused by a DSP mutation. The pattern of delayed enhancement of gadolinium is not specific for genetic heart disease, but is distinct from ischemic cardiomyopathy. LV = left ventricle; RV = right ventricle. Images courtesy of Ravi Shah, MD and Raymond Kwong, MD, Brigham and Women’s Hospital, Boston, MA.
See this image and copyright information in PMC

References

    1. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Aurora P, Christie J, Dobbels F, Rahmel AO, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report--2007. J Heart Lung Transplant. 2007;26:769–781. - PubMed
    1. Felker GM, Thompson RE, Hare JM, Hruban RH, Clemetson DE, Howard DL, Baughman KL, Kasper EK. Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy. N Engl J Med. 2000;342:1077–1084. - PubMed
    1. Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ, Jr, Spudich S, De Girolami U, Seidman JG, Seidman C, Muntoni F, Muehle G, Johnson W, McDonough B. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med. 1999;341:1715–1724. - PubMed
    1. Kamisago M, Sharma SD, DePalma SR, Solomon S, Sharma P, McDonough B, Smoot L, Mullen MP, Woolf PK, Wigle ED, Seidman JG, Seidman CE. Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy. N Engl J Med. 2000;343:1688–1696. - PubMed
    1. Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE. Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban. Science. 2003;299:1410–1413. - PubMed

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