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Comment
. 2012 Oct;20(10):1839-41.
doi: 10.1038/mt.2012.192.

Pushing the reset button: chemical-induced conversion of amniotic fluid stem cells into a pluripotent state

Sebastian Diecke  1 , Joseph C Wu
Affiliations
Comment

Pushing the reset button: chemical-induced conversion of amniotic fluid stem cells into a pluripotent state

Sebastian Diecke et al. Mol Ther. 2012 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Developmental fates of embryonic and adult stem cells. During development it is possible to isolate pluripotent cells at different stages. Moreover, several reprogramming techniques now allow the induction of pluripotency to terminal differentiated cell types (iPS, induced pluripotent stem cell). Amniotic fluid stem cells (AFSCs) can easily be derived within the first trimester of pregnancy. AFSCs most likely originate from primordial germ cells (PGCs), and treatment with the histone deacetylase inhibitor valproic acid (VPA) converted these multipotent cells into pluripotent cell type. Therefore, the transcriptome of AFSCs is presumably comparable to the transcriptome of embryonic germ cells (EGCs). ASC, adult stem cell; ESC, embryonic stem cell; EpiSC, epiblast stem cell.
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References

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