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Review
. 2012 Oct;130 Suppl 1(Suppl 1):S44-6.
doi: 10.1016/j.thromres.2012.08.272.

Formation of the clot

Bruce Furie  1 , Barbara C Furie
Affiliations
Review

Formation of the clot

Bruce Furie et al. Thromb Res. 2012 Oct.

Abstract

An electron transport system regulates the initiation of thrombus formation through the activation of critical receptors involved in hemostasis and thrombosis. Protein disulfide isomerase along with other thiol isomerases, important for intracellular protein synthesis, are responsible for this extracellular activity during thrombus formation. Inhibition of these thiol isomerases blocks platelet aggregation and fibrin generation. Pharmaceuticals directed against these thiol isomerases offers a novel approach to antithrombotic therapy.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors do not acknowledge any relevant conflicts of interest.

References

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    1. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, et al. Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin. J Exp Med. 2003;197:1585–98. - PMC - PubMed
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    1. Sim DS, Merrill-Skoloff G, Furie BC, Furie B, Flaumenhaft R. Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood. 2004;103:2127–34. - PubMed

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