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Case Reports
. 2012 Dec;56(12):6430-1.
doi: 10.1128/AAC.01787-12. Epub 2012 Oct 1.

A case of daptomycin-induced immune thrombocytopenia

Charles Grégoire  1 , Caren Brumpt, Delphine Loirat, Nicolas Lau, Cedric Bruel, Francois Philippart, Carine Couzigou, Maité Garrouste-Orgeas, Benoit Misset
Affiliations
Case Reports

A case of daptomycin-induced immune thrombocytopenia

Charles Grégoire et al. Antimicrob Agents Chemother. 2012 Dec.

Abstract

We report a case of severe daptomycin-induced immune thrombocytopenia in a patient treated for methicillin-resistant Staphylococcus epidermidis and ampicillin-resistant Enterococcus faecalis bacteremia acquired in an intensive care unit. Serum antibodies bound to platelets in the presence of daptomycin on flow cytometry. There was no evidence of other causes of thrombocytopenia. The patient died of brain herniation complicating extensive cerebral hemorrhage. To our knowledge, this is the first described case of daptomycin-induced thrombocytopenia.

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Figures

Fig 1
Fig 1
Flow cytometry analysis for the presence of a daptomycin-dependent, platelet-reactive antibody. The platelet median fluorescence intensity (MFI) was significantly higher with the patient's serum plus daptomycin (MFI, 4,325) than with the patient's serum plus buffer (MFI, 1,494) or normal serum plus daptomycin (MFI, 1,829). No such difference occurred with piperacillin-tazobactam (left).
See this image and copyright information in PMC

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