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. 2012 Oct 1;17(10):11721-8.
doi: 10.3390/molecules171011721.

A new saponin from tea seed pomace (Camellia oleifera Abel) and its protective effect on PC12 cells

Xin-Fu Zhang  1 , Ying-Ying Han, Guan-Hu Bao, Tie-Jun Ling, Liang Zhang, Li-Ping Gao, Tao Xia
Affiliations

A new saponin from tea seed pomace (Camellia oleifera Abel) and its protective effect on PC12 cells

Xin-Fu Zhang et al. Molecules. .

Abstract

A new triterpenoid saponin, oleiferasaponin A₁, was isolated from tea seed pomace (Camellia oleifera Abel). The structure of oleiferasaponin A₁ was elucidated on the basis of chemical and physicochemical evidence and was found to be 22-O-cis-2-hexenoyl-A₁-barrigenol 3-O-[β-D-galactopyranosyl(1→2)] [β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid. PC12 cells injured with H₂O₂ were used as the model to test the protective effects of oleiferasaponin A₁. The results indicated that oleiferasaponin A₁ can potentially prevent the H₂O₂-induced cell death of PC12 cells.

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Figures

Figure 1
Figure 1
2D NMR correlations and MS/MS fragmentation of oleiferasaponin A1.
Figure 2
Figure 2
Cell protective effects of oleiferasaponin A1 on H2O2-induced cytotoxicity in PC12 cells (n = 8). A, 5 mM H2O2; B, 5 mM H2O2 + 5 μM oleiferasaponin A1; C, 5 mM H2O2 + 25 μM oleiferasaponin A1; D, 5 mM H2O2 + 125 μM oleiferasaponin A1; The values are expressed as mean ± SD. ** p < 0.01 with respect to the H2O2 group.
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References

    1. Chen Y.F., Yang C.H., Chang M.S., Ciou Y.P., Huang Y.C. Foam properties and detergent abilities of the saponins from Camellia oleifera. Int. J. Mol. Sci. 2010;11:4417–4425. doi: 10.3390/ijms11114417. - DOI - PMC - PubMed
    1. Chaicharoenpong C., Petsom A. Quantitative thin layer chromatographic analysis of the saponins in tea seed meal. Phytochem. Anal. 2009;20:253–255. doi: 10.1002/pca.1123. - DOI - PubMed
    1. Huang Q., He M., Chen H., Shao L., Liu D., Luo Y., Dai Y. Protective effects of sasanquasaponin on injury of endothelial cells induced by anoxia and reoxygenation in vitro. Basic Clin. Pharmacol. 2007;101:301–308. doi: 10.1111/j.1742-7843.2007.00119.x. - DOI - PubMed
    1. Huang Q., Shao L., He M., Chen H., Liu D., Luo Y., Dai Y. Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats. Burns. 2005;31:637–642. doi: 10.1016/j.burns.2005.02.006. - DOI - PubMed
    1. Morikawa T., Li N., Nagatomo A., Matsuda H., Li X., Yoshikawa M. Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis) J. Nat. Prod. 2006;69:185–190. doi: 10.1021/np058097w. - DOI - PubMed

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