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Editorial
. 2012 Oct 2;126(14):1678-80.
doi: 10.1161/CIRCULATIONAHA.112.134379.

Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis

Ellen O Weinberg, Caroline Attardo Genco
Editorial

Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis

Ellen O Weinberg et al. Circulation. .
No abstract available

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Figures

Figure
Figure
Cell specificity of TRAF6 signaling in atherosclerosis. The study by Polykratis et al reveals the effects of cell-specific deletion of the adaptor molecule TRAF6 on the development of high-fat diet–induced atherosclerosis. Deletion of TRAF6 in endothelial cells resulted in diminished atherosclerosis in female mice. In contrast, increased atherosclerosis was observed in male and female mice with deletion of TRAF6 in myeloid/macrophage cells. ER indicates endoplasmic reticulum; IL, interleukin; TLR, Toll-like receptor; TRAF6, tumor necrosis factor receptor–associated factor; and VCAM, vascular cell adhesion molecule.
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