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Review
. 2012:2012:629452.
doi: 10.1155/2012/629452. Epub 2012 Sep 17.

Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy

Daniel Gologorsky  1 , Aristomenis Thanos, Demetrios Vavvas
Affiliations
Review

Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy

Daniel Gologorsky et al. Mediators Inflamm. 2012.

Abstract

The global prevalence of diabetes is estimated to be 336 million people, with diabetic complications contributing to significant worldwide morbidity and mortality. Diabetic retinopathy results from cumulative microvascular damage to the retina and inflammation is recognized as a critical driver of this disease process. This paper outlines the pathophysiology leading to proliferative diabetic retinopathy and highlights many of the inflammatory, angiogenic, and cytokine mediators implicated in the development and progression of this disease. We focus a detailed discussion on the current targeted therapeutic interventions used to treat diabetic retinopathy.

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Figures

Figure 1
Figure 1
Normal eye (a) with intact vasculature (b). Accumulation of microvascular diabetic changes in the eye (c) manifest in adverse cellular changes with ultimate compromise to the blood-retinal-barrier (d).
See this image and copyright information in PMC

References

    1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice. 2010;87(1):4–14. - PubMed
    1. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice. 2011;94(3):311–321. - PubMed
    1. Gustavsson C, Agardh CD, Agardh E. Profile of intraocular tumour necrosis factor-alpha and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy. Acta Ophthalmologica, http://www.ncbi.nlm.nih.gov/pubmed/22520269. In press. - PubMed
    1. Adamis AP. Is diabetic retinopathy an inflammatory disease? British Journal of Ophthalmology. 2002;86(4):363–365. - PMC - PubMed
    1. Shamoon H, Duffy H, Fleischer N, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The New England Journal of Medicine. 1993;329(14):977–986. - PubMed

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