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Comment
. 2012 Sep;8(9):e1002989.
doi: 10.1371/journal.pgen.1002989. Epub 2012 Sep 20.

GWAS of diabetic nephropathy: is the GENIE out of the bottle?

Carsten A Böger  1 , John R Sedor
Affiliations
Comment

GWAS of diabetic nephropathy: is the GENIE out of the bottle?

Carsten A Böger et al. PLoS Genet. 2012 Sep.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Schematic presentation of variable clinical courses of diabetic nephropathy.
The case and control definitions used in the primary GWAS in Sandholm et al. are indicated by green bold (controls) and red double-lined boxes (cases). GFR, glomerular filtration rate; ESRD, end stage renal disease. Microalbuminuria, urinary albumin excretion rate of 30–300 mg per day; macroalbuminuria, urinary albumin excretion rate of >300 mg per day. *, GFR and albuminuria may progress independently of each other, i.e., patients may have micro- or macroalbuminuria even though their GFR is normal or even slightly elevated. However, macroalbuminuria is usually associated with reduced GFR, and is a strong risk factor for progressive loss of eGFR and ESRD.
See this image and copyright information in PMC

Comment on

  • New susceptibility loci associated with kidney disease in type 1 diabetes.
    Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola AJ, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Lithovius R, Osterholm AM, Parkkonen M, Pitkäniemi J, Rosengård-Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini SM; DCCT/EDIC Research Group; Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Ioana M, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Groop L, Lajer M, Bull SB, Waggott D, Paterson AD, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Florez JC, Groop PH, Maxwell AP. Sandholm N, et al. PLoS Genet. 2012 Sep;8(9):e1002921. doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20. PLoS Genet. 2012. PMID: 23028342 Free PMC article.

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