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. 2012;6(9):e1752.
doi: 10.1371/journal.pntd.0001752. Epub 2012 Sep 27.

Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials

Cameron P Simmons  1 , Marcel Wolbers, Minh Nguyet Nguyen, Jamie Whitehorn, Pei Yong Shi, Paul Young, Rosemary Petric, Van Vinh Chau Nguyen, Jeremy Farrar, Bridget Wills
Affiliations

Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials

Cameron P Simmons et al. PLoS Negl Trop Dis. 2012.
No abstract available

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Conflict of interest statement

The authors have read the journal's policy and have the following conflicts. Rosemary Petric is an employee of Hoffmann-La Roche, USA. Pei-Yong Shi is an employee of the Novartis Institute of Tropical Diseases, Singapore. Cameron Simmons is a consultant to Unither Virology LLC. The corresponding author (CPS) takes responsibility for the content of this paper and the decision to submit for publication.

Figures

Figure 1
Figure 1. Suggested minimum schedule of assessments for a trial of a candidate therapeutic in a patient population with <48 h of fever at the time of commencing treatment.
See this image and copyright information in PMC

References

    1. Tricou V, Minh NN, Van TP, Lee SJ, Farrar J, et al. (2010) A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults. PLoS Negl Trop Dis 4: e785 doi:10.1371/journal.pntd.0000785. - DOI - PMC - PubMed
    1. Nguyet NM, Chau TNB, Lam PK, Kien DTH, Huy HlA, et al. (2012) A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis In Press. - PMC - PubMed
    1. Tam DTH, Ngoc TV, Tien NTH, Kieu NTT, Thuy TTT, et al. (2012) A randomized placebo controlled trial to investigate the effects of short course oral corticosteroid therapy in early dengue infection in Vietnamese patients. Clin Infect Dis In Press. - PMC - PubMed
    1. Simmons CP, Farrar JJ, Nguyen vV, Wills B (2012) Dengue. N Engl J Med 366: 1423–1432. - PubMed
    1. Halstead SB (2007) Dengue. Lancet 370: 1644–1652. - PubMed

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